• Research
  • Major Research Areas
  • Development of novel drugs against tuberculosis and its multiresistent forms as a perspective of TB treatment

Development of novel drugs against tuberculosis and its multiresistent forms as a perspective of TB treatment

Development of novel drugs against tuberculosis and its multiresistent forms as a perspective of TB treatment


The project deals with the development of novel antitubercular agents active against resistant strains of Mycobacterium tuberculosis, dissemination of which is a serious global problem. The project is based on the collaboration of the Faculty of Pharmacy of the Charles University in Prague and Centre of Biological Defence in Těchonín. Faculty of Pharmacy deals with the design and synthesis of new molecules, evaluation of their toxicity and in vitro antimycobacterial activity, and with the determination of their mechanism of action. The evaluation of in vivo antimycobacterial aktivity is performed in Centre of Biological Defence in Těchonin, specialized institute fully equipped for handling with the most dangerous infection agents. Moreover, in vivo antituberculosis evaluation is not performed anywhere in the central Europe, therefore this research is unique in this European region.


Selected outputs

  • WO 2014/161516 (PCT/CZ2013/000131) Hrabálek A., Roh J., Karabanovich G., Klimešová V., Němeček J., Pávek P.: Oxa- and thia-diazoles useful in the treatment of Tuberculosis.

  • Karabanovich G., Roh J., Padelková Z., Novák Z., Vávrová K., Hrabálek A. One-pot synthesis of 1-substituted-5-alkylselanyl-1H-tetrazoles from isoselenocyanates: unexpected formation of N-alkyl-N-arylcyanamides and (Z)-Se-alkyl-N-cyano-N,N '-diarylisoselenoureas. Tetrahedron 69 (41), 2013, p. 8798-8808.

  • Karabanovich G., Roh J., Smutný T., Němeček J., Vicherek P., Stolaříková J., Vejsová M., Dufková I., Vávrová K., Pávek P., Klimešová V., Hrabálek A. 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogues: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistent mycobacteria. Eur. J. Med. Chem. 82, 2014, p. 324-340.


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