• Research
  • Major Research Areas
  • Study of Drugs and Other Biologically-Active Substances Perspective in Prevention and Treatment of Important Lifestyle Diseases

Study of Drugs and Other Biologically-Active Substances Perspective in Prevention and Treatment of Important Lifestyle Diseases

Study of Drugs and Other Biologically-Active Substances Perspective in Prevention and Treatment of Important Lifestyle Diseases

The aim of the project is to study newly used drugs in clinical medicine as well as biologically‑active substances of natural origin from the perspective of the prevention and treatment of important lifestyle diseases, especially cardiovascular and oncologic diseases and degenerative diseases associated with human ageing. The project involves studying the influence of significant biological markers in the early diagnosis of these diseases along with the identification of new potential biomarkers and the isolation and identification of new enzymes as a potential targets for the inhibition associated with the therapy of these diseases. An integral part of the project is the isolation and identification of new substances of natural origin, especially those with anti‑oxidation activity in relation to the prevention of cardiovascular and oncologic diseases.


This multi‑discipline project directly follows and significantly extends the collaboration of perspective researchers from several departments of the Faculty of Pharmacy, Charles University in Hradec Králové dealing with study of effect of biologically active compounds in the prevention and treatment of lifestyle diseases.


Selected outputs

  • Hofman J., Skarka A., Havránková J., Wsól V.: Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases. Biochemical Pharmacology, 96, 2015, 168-178.

  • Vlčková H., Svoboda P., Novák O., Solich P., Nováková L.: Development of MEPS-UHPLC-MS/MS multistatin methods for clinical analysis. Bioanalysis, 8 (4), 2016, 333-349.

  • Zelená L., Marques S.S., Segundo M., Miro M., Pávek P., Sklenářová H., Solich P.: Fully automatic flow-based device for monitoring of drug permeation across a cell monolayer. Anal. Bioanal. Chem., 408 (3), 2016, 971-981.

  • Malátková P., Sokolová S., Chocholoušová Havlíková L., Wsól V.: Carbonyl reduction of warfarin: Identification and characterization of human warfarin reductases. Biochemical Pharmacology, 109, 2016, 83-90.

  • Červinková B., Kujovská-Krčmová L., Solichová D., Melichar B., Solich P.: Recent advances in the determination of tocopherols in biological fluids: from sample pre-treatment and liquid chromatography to clinical studies. Anal.Bioanal.Chem. 408, 2016, 2407–2424.


Last change: August 22, 2017 16:07 
Share on:  
Contact Us
Contact

Charles University

Ovocný trh 5

Prague 1

116 36

Czech Republic


Centre for Information, Counselling and Social Services

E-mail:

Phone: +420 224 491 850


Public Relations Officer

E-mail:   

Phone: +420 224 491 248


Data Box ID: piyj9b4

ID No.: 00216208

VAT No.: CZ00216208


How to Reach Us