List of Post-Doctoral Fellowships

Involved faculties and institutes:


1. Center for Economic Research and Graduate Education-Economics Institute

2. Faculty of Law

3. Faculty of Mathematics and Physics

4. Faculty of Medicine in Pilsen

5. Faculty of Pharmacy in Hradec Králové

6. Faculty of Science

7. Faculty of Social Sciences

8. First Faculty of Medicine





Center for Economic Research and Graduate Education - Economics Institute (CERGE-EI)


Empirical microeconomics, development, organizational and labor economics


CERGE UK seeks a postdoctoral candidate with focus on empirically oriented research in microeconomics, development economics, organizational economics, or labor economics. Preference will be given to candidates pursuing research spanning across the above fields. Applicants should demonstrate the capacity to pursue a research project at the frontier of current knowledge as well as the ability to achieve a strong publication record in leading scholarly journals.




Faculty of Law


“The approximation of European taxation systems; considerations on the divisions of tax competences and the exercise of taxing power“




Faculty of Mathematics and Physics


1. Call for PostDoc Position in the area of Numerical methods for high-performance scientific computing

Post-doc position for one-year period from 1st January 2017

Faculty of Mathematics and Physics, Charles University in Prague


Research Project


A significant part of progress in scientific computing for solving large real-world problems naturally stems from new mathematical approaches. Moreover, the whole process from the problem formulation through its mathematical description, corresponding analysis, discrete representation, solving the discretized problem up to verification of computed results represents a holistic task whose parts cannot be separated from each other. The solution process typically involves various and often distant mathematical disciplines connected by the need to use high performance computational tools.


High-performance computing systems use extreme parallelism in performing computations. This requires adequate methods, algorithms and implementations, with emphasize on their theoretical analysis, investigation of numerical stability, accuracy of computations, robustness, resilience, and low computational cost. The research of numerical methods complying with the demands of high-performance computing will be conducted in the Department of Numerical Methods, Faculty of Mathematics and Physics, Charles University in Prague, in the team led by Zdeněk Strakoš and Miroslav Tůma.


Applicants should have a PhD. in mathematics or in computer science, with a background in computational mathematics, in particular numerical analysis and/or matrix computations.


Contact person:

Prof. Ing. Zdeněk Strakoš, DrSc. Charles University in Prague, Faculty of Mathematics and Physics Institute of Physics, Department of Numerical Mathematics

e-mail:


Applicants should submit:


  • Application form

  • Letters of Reference

  • Detailed CV

  • List of publications

  • Copy of university diploma


Deadline date: 26th August 2016




2. Call for PostDoc Position in the area of Low-energy hadron interactions at the precision frontier

Post-doc position for one-year period from 1st January 2017

Faculty of Mathematics and Physics, Charles University in Prague


Research Project


The suitable candidate should have good knowledge of both theoretical aspects of quantum field theory, especially quantum chromodynamics and electroweak theory and also awareness of present experimental facilities connected with studied problems. During the postdoc period we want to focus on two main objectives:


1. Detailed scrutiny of the physics of the pion at low energies with emphasis on the potential indirect discovery of new physics. First it is important to resume the main decay channels, collect the main results and discussions, and provide a roadmap towards an improvement of both the theoretical calculation and the experimental determination. The report should help to promote the pseudoscalar physics program at NA62 and other infrastructures.


2. Develop the theoretical formalism within the chiral perturbation theory in the anomalous sector of QCD at low energies including singlet contributions to calculate at the loop level the pseudoscalar Dalitz decay for pion, eta, and eta' mesons. Explore the pattern of lepton flavor violation and lepton flavor universality violation of their decays within the SM.


Contact person:

Doc. K. Kampf, Ph.D., Charles University in Prague, Faculty of Mathematics and Physics, Institute of Particle and Nuclear Physics

e-mail:


Applicants should submit:


  • Application form

  • Letters of Reference

  • Detailed CV

  • List of publications

  • Copy of university diploma


Deadline date: 26th August 2016




3. Call for PostDoc Position in the area of Plasma transport from the solar wind to the Earth’s magnetosphere

Post-doc position for one-year period from 1st January 2017

Faculty of Mathematics and Physics, Charles University in Prague


Research Project


A plasma entering the magnetosphere should cross two principal boundaries – bow shock and magnetopause. The crossing of the bow shock modifies significantly plasma parameters as well as the direction and magnitude of the frozen-in interplanetary magnetic field creating a key region for a transfer of solar wind mass and momentum to the magnetosphere – the magnetosheath. A highly turbulent magnetosheath plasma and magnetic field then interact with the magnetopause and can penetrate deeper into the magnetosphere. Magnetic reconnection, Kelvin-Helmholtz instability, and diffusive mechanisms such as wave-particle interactions were identified as main physical mechanisms facilitating energy, momentum, and mass transport across the magnetopause. Nevertheless, variety of phenomena like interaction of the upstream current sheets with the bow shock or supersonic plasma jets in the magnetosheath may contribute to this transport but their role isn’t still well understood.


The project is directed to discuss particular aspects of the plasma transport across the boundaries and the related phenomena like the influence of the boundary processes on the geomagnetic activity in a general sense. An attention can be focused on (1) a possible role of foreshock effects (turbulence, foreshock cavities, energetic particles); (2) an interaction of solar wind reconnection outflows with the bow shock and magnetopause; (3) a leakage of magnetospheric particles into the magnetosheath; (4) transient processes at the magnetopause and their sources (e.g., HFAs, foreshock bubbles, magnetosheath fluctuations); and (5) a magnetosphere response represented by auroral and/or ground based observations to variations of upstream drivers (magnetic field strength and orientation and plasma parameter changes).


Research garant:

Prof. Z. Němeček, DrSc., Charles University in Prague, Faculty of Mathematics and Physics, Department of Surface and Plasma Science

e-mail:


Applicants should submit:


  • Application form

  • Letters of Reference

  • Detailed CV

  • List of publications

  • Copy of university diploma


Deadline date: 26th August 2016




4. Call for PostDoc Position in the area of Transport properties of actinide

Post-doc position for one-year period from 1st January 2017

Faculty of Mathematics and Physics, Charles University in Prague


Research Project


A post-doctoral research fellow will join existing projects focusing on electronic properties of actinides (mainly uranium) systems and other materials with strong electron-electron correlations. The focus will be on transport properties and the main task will be practical implementation and pursuing of less common transport studies, as Hall effect, thermopower and thermal conductivity, using existing low temperature facilities. An applicant should have PhD. in physics or materials science, previous experience with transport studies and/or strongly correlated systems is advantage.


Research garant:

Doc. L. Havela, CSc., Charles University in Prague, Faculty of Mathematics and Physics, Department of Condensed Matter Physics

e-mail:


Applicants should submit:


  • Application form

  • Letters of Reference

  • Detailed CV

  • List of publications

  • Copy of university diploma


Deadline date: 26th August 2016




5. Call for PostDoc Position in the area of Automated Planning and Scheduling

Post-doc position for one-year period from 1st January 2017

Faculty of Mathematics and Physics, Charles University in Prague


Research Project


Major goal of work is designing models and algorithms for automated planning and scheduling with relation to plan execution in uncertain environments. Planning and scheduling is usually handled off-line without direct relation to plan execution. However, dynamic environments, for example in robotics, require modification of plans (re-planning) based on disturbances and unexpected changes in the environment. Another approach is designing flexible plans that can be modified during execution to minimize the number of re-planning stages. The work is motived by needs of a robotic group and possible industrial users and the developed techniques are supposed to be immediately applicable. The project involves formal problem modelling as well as design of algorithms.


The work will be supervised by Prof. Roman Barták, Dept. of Theoretical Computer Science and Mathematical Logic, Faculty of Mathematics and Physics, Charles University in Prague.


Applicant should have a PhD. in computer science, preferably artificial intelligence with a strong background in planning and scheduling. Experience with real life projects is an advantage.


Contact person:

Prof. Roman Barták, Charles University in Prague, Faculty of Mathematics and Physics Institute of Physics, Dept. of Theoretical Computer Science and Mathematical Logic

e-mail:


Applicants should submit:


  • Application form

  • Letters of Reference

  • Detailed CV

  • List of publications

  • Copy of university diploma


Deadline date: 26th August 2016




6. Call for PostDoc Position in the area of Fast accesing data using parallel architecture

Post-doc position for one-year period from 1st January 2017

Faculty of Mathematics and Physics, Charles University in Prague


Research Project


The area of project is aimed at modelling, design and development of highly efficient parallel methods for accessing complex unstructured data. In particular, access to very large graph-based data in domains of social networks and network security are the subject of research, as well as processing feature descriptors of multimedia objects, time series and other unstructured data entities. As the hardware platforms, there are considered servers/farms equipped by GPU cards Nvidia Tesla and/or Intel Xeon Phi cards. The long-term goal exceeding the time frame of the project is the development of methods for big data analytics.


The postdoc applicant is supposed to join researchers at the Department of Software Engineering. The applicant should have strong experience with implementation of parallel algorithms on the mentioned hardware platforms, as well as the ability to create formal abstract models in the field of parallel algorithms design.


Contact person:

Doc. RNDr. Tomáš Skopal, Ph.D., Charles University in Prague, Faculty of Mathematics and Physics Institute of Physics, Department of Software Engineering

e-mail:


Applicants should submit:


  • Application form

  • Letters of Reference

  • Detailed CV

  • List of publications

  • Copy of university diploma


Deadline date: 26th August 2016




Faculty of Medicine in Pilsen


1. Molecular and bio-functional understanding of sepsis-induced organ dysfunction and hypothesis-driven design of new treatment concepts – translational experimental research program


Position available from: January 2017


Department: Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague


Laboratory: Laboratory of Experimental Intensive Care Medicine


Supervisor:

Martin Matejovic, M.D., Ph.D. Professor of Medicine

E-mail:

Phone: +420 377 103 501


Input premise


Sepsis is estimated to kill tens of millions of people worldwide annually. In the United States alo­ne, approximately 215 000 die of sepsis each year – more than breast cancer, colon cancer, and HIV/AIDS combined and similar numbers are reported in Europe. Despite these staggering losses, few specific therapeutic options are available to treat sepsis. Laboratory of Experimental Intensive Care Medicine aims to investigate molecular and bio-functional understanding of sepsis-induced organ dysfunction and design hypothesis-driven new treatment concepts in highly translational experimental porcine models. In addition the laboratory has taken a leading role both nationally and internationally in creating dynamic animal modeling of sepsis-induced acute kidney injury as well as in testing novel methods of extracorporeal organ replacement and blood purification techniques. The three following central projects that will closely interact with each other, combining basic sci­ence and clinical expertise will be addressed: 1) understanding of the acute danger response on a molecular, cellular, microvascular, organ (in particular kidney), and organism level; 2) therapeutic potential of mitochondria/microcirculation-focused novel molecules; 3) therapeutic potential of me­senchymal stem cells in sepsis and acute kidney injury.


Additional Information

http://www.biomedic-plzen.cz/en/200-laboratory-of-experimental-intensive-care-medicine


Qualifications


  • Ph.D. (or equivalent) degree in medicine recently graduated

  • Proven expertise in the development and characterization of animal models of disease

  • Basic clinical skills in intensive care medicine

  • Good knowledge of sepsis, inflammation and related problem

  • Highly motivated scientists with strategic decision-making skills

  • Excellent English communication skills both in written and oral form

  • Track record of publications in peer-reviewed journals (at least 3 publications in IF journals, two as a first author)


The applicants should submit


  • Letter of Reference

  • Curriculum vitae

  • List of publications

  • Copy of university diploma

  • Brief description of prior research, skills and experiences





2. Identification of different cells interaction with silicon nanoparticles with their application in bio-medicine


Position available from: January 2017


Department: Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague


Laboratory: Laboratory of Cell-Biomaterial Interactions


Supervisor:

Assoc. Prof. RNDr. Marie Hubalek Kalbacova, Ph.D.

E-mail:

Phone: +420 224 967 155


Input premise


Nanoparticles of different types have been widely used in bio-medicine in past several years; howe­ver their interactions with cells are still not well understood. Nanoparticles used in our lab are sili­con-based and their composites could be used for visualization within the cells as well as for drug/ gene delivery. To fulfill this aim, deep study of the entry of different nanoparticles into the cells, their movement and localization as well as possible escape from the cell is needed. To characterize the cell-nanoparticle interaction methods of molecular biology and biochemistry (assays, ELISA, Wes­tern blot, etc.), confocal microscopy with subsequent image analysis, Raman spectroscopy, atomic force microscopy as well as other physical methods will be used.


The aims of the project will be a) to establish the pathway used for different silicon based nanopar­ticles to enter different cell types b) to investigate the impact of the conditions on the nanoparticles cell entry and c) to investigate the application of silicon based nanoparticles as a vehicle for gene delivery.


Additional Information

http://www.biomedic-plzen.cz/en/218-laboratory-of-cell-biomaterial-interactions

http://udmp.lf1.cuni.cz/en/interaction-of-cells-with-nanomaterials


Qualifications


  • Ph.D. degree in physiology/biology/life sciences – recently graduated.

  • Practical experience with cell culture, cellular physiology assays (proliferation, adhesion, migra­tion), fluorescence and/or confocal microscopy and live cell imaging, gene and protein expre­ssion analysis (qPCR, microarray technology, ELISA, western blot), immunocytochemistry, flow cytometry.

  • High motivation, desire to undertake significant/cutting-edge scientific research, team spirit as well as capable of independent work, organization skills (interdisciplinary collaborative rese­arch, project/grant management, students education), communication skills (in the research team, inter-group, presentation of scientific results – oral and written form).

  • Track record of at least 4 topic related publications in impacted journals (IF > 2), at least 2 of them as the first author.

  • Excellent English communication at both written and oral level.


The applicants should submit


  • Curriculum vitae

  • List of publications

  • Two letters of reference

  • Brief description of prior research, skills and experiences (no more than one page)

  • Copy of university diploma




3. Development of rapid microbiological methods for rational antibiotic therapy


Position available from: January 2017


Department: Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague


Laboratory: Laboratory of Antibiotic Resistance and Applications of Mass Spectrometry in Microbiology


Supervisor:

Jaroslav Hrabak, Ph.D., M.Sc. Associate Professor of Medical Microbiology

E-mail:

Phone: +420 377 593 801


Input premise


Antibiotic resistance is an emerging problem worldwide. Increasing trends of antibiotic-resistant bacteria, causing infections in humans, have been reported by many European countries. Emergen­ce of antibiotic resistant bacteria has complicated the antibiotic treatment of infectious diseases and significantly increased its cost. As a consequence, several reports describing the failure of antibiotic treatment schemes used in humans have emerged the last years.


Scientific activities of Laboratory of Antibiotic Resistance and Application of Mass spectrometry in Microbiology (ARAMM) are mainly focused on mechanisms of resistance to antibiotics, especially to expanded-spectrum cephalosporins and carbapenems, in Gram-negative bacteria (Enterobacteria­ceae, Pseudomonas spp.). The research projects aim to execute molecular epidemiology of factors affecting dissemination of multi-drug resistance among nosocomial pathogens. Methodological approaches, also, include analysis of genetic carriers of resistance determinants and whole-ge­nome sequencing. The second main objective of the research projects is intending in the develop­ment of new techniques for the detection and study of resistance mechanisms using MALDI-TOF mass spectrometry and Raman spectroscopy. In 2011, the members of our group demonstrated that MALDI-TOF mass spectrometry can directly detect carbapenemase activity. Also, recently, we patented a method for the identification of β-lactamases in clinical isolates by MALDI-TOF mass spectrometry, based on their molecular weight.



4. The involvement of ubiquitin-proteasomal system in epigenetic regulation of mammalian embryogenesis


Position available from: January 2017


Department: Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague


Laboratory: Laboratory of Reproductive Medicine


Supervisor:

Jan Nevoral, Ph.D., M.Sc.

E-mail:

Phone: +420 377 593 808


Input premise


Success of reproductive medicine and assisted reproductive technologies (ART) depends on results of in vitro fertilization (IVF) and subsequent in vitro culture of pre-implanted embryos (IVC). Process of fertilization means the zygote creation, i. e. fusion of two terminally differentiated gametes onto one-cell embryo. Dynamic changes of zygote de-diferentiation lead to genesis of totipotent zygotes. These de-differentional zygote changes include ubiquitin-proteasomal system (UPS) action resulting in genome modifications without changes of DNA sequence, called epigenetic changes. These changes are regulated by up-stream factors remaining still uncovered.


DNA methylation, one of such epigenetic changes, affects DNA through methyl addition to cytosine. In addition to DNA, the methylation targets core histones as well and therefore histone methylation signifficatly determines histone code, an aglomeration of post-translational modifications of core histones. Adequate epigenetic changes, such as DNA methylation and histone methylation, lead to gene silencing, heterochromatin establishment, genome stabilization and cell differentiation. The involvement of UPS in epigenetic regulation is indicated, however, underlying molecular mechanism are still unexplained and many factors remain unknown.


Obviously, non-adequate epigenetic changes cause failure of IVF/IVC and thus ART. Study of epigenetic regulating factors in zygotes and early embryos offers an increase in ART success. The aim of thesis is to prove up-stream factor-driven epigenetics which allows IVF/IVC improvement.


Additional Information

http://www.biomedic-plzen.cz/en/404-laboratory-of-reproductive-medicine


Qualifications


  • Ph.D. degree in physiology/biology/life sciences – recently graduated.

  • Practical experience with oocyte and/or sperm manipulation, immunocytochemistry followed by fluorescent and/or confocal microscopy, basic boiochemical analysis (ELISA, western blot).

  • In addition to required experiences, following are considered as an advantage: small animals (in particular mice) handling, live cell imaging, microinjection and micromanipulation, flow cytometry and cell sorting.

  • Track record of at least 4 topic related publications in indexed journals with impact factor, at least 2 of them as the first author.

  • English communication at both written and oral.


The applicants should submit


  • Curriculum vitae

  • List of publications

  • Two letters of reference

  • Brief description of prior research, skills and experiences (no more than one page)

  • Copy of university diploma




5. Identification of novel prognostic and predictive modalities in colorectal cancer


Position available from: January 2017


Department: Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague


Laboratory: Laboratory of Tumor biology


Supervisor:

Pavel Pitule, Ph.D., M.Sc.

E-mail:

Phone: +420 377 593 845


Input premise


Malignant diseases are among the principal causes of death worldwide and colorectal cancer in particular is one of the three most common types of cancer regarding both incidence and mortality. Its treatment is complicated by the great heterogeneity among the individual tumors and we are still far from complete understanding to mechanisms that drive growth, evolution and spreading of this type of cancer.


The research of colorectal cancer in our laboratory has two main branches. First, we are focused on identification of novel molecular markers and signatures in tumor tissue that could be used for classification of individual patients with the goal to assign them to optimal treatment regime. Se­cond program is targeted on analysis of peripheral blood for monitoring of patients during the tre­atment. This includes detection and analysis of free circulating nucleic acids and circulating tumor cells to assess disease response to the therapy and to improve prediction of possible recurrences. Both of these branches has common greater goal to analyze heterogeneity of colorectal cancer and effects of the individual characteristics on the clinical behavior of the tumor.


The research goal for the postdoc position will be to work on deciphering relations among tumor characteristics and clinical outcomes with the special focus on the heterogeneity of circulating tu­mor cell populations and cellular composition of primary tumor samples.


Additional Information

http://www.biomedic-plzen.cz/en/219-laboratory-of-tumor-biology


Qualifications


  • Ph.D. (or equivalent) degree in molecular biology, genetics, oncology or related field

  • Experience with molecular and cell culture techniques e.g. cell cultivation, immunochemistry, microscopy, real time quantitative PCR, RT-PCR and related molecular biology methods. Ex­perience with microarray, next generation sequencing and data analysis from high-throughput methods is advantage.

  • High motivation, ability to conduct collaborative research

  • Good English communication skills both in written and oral form

  • Track record of publications in peer-reviewed journals, at least 4 publications in IF journals, two as a first author


The applicants should submit


  • Letter of Reference

  • Curriculum vitae including description of prior research, skills and experiences

  • List of publications

  • Copy of university diploma

  • Motivational letter





6. Identification of mechanisms responsible for regenerative potential of mesenchymal stem cells


Position available from: January 2017


Department: Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague


Laboratory: Laboratory of Cellular Regenerative Medicine


Supervisor:

Lucie Vistejnova, Ph.D., M.Sc.

E-mail:

Phone: +420 377 593 820


Input premise


Bone marrow derived mesenchymal stem cells (MSCs) have been proposed as a promising cell-ba­sed therapeutical approach in the regeneration of various tissues including bone, cartilage, skeletal or cardiac muscles or even liver and nerves. MSCs are adherent cells positive for CD90, CD29, CD44, CD105, CD73, negative for CD34 and CD45 and able to differentiate into chondro-, osteo-, and adipo-cell types.


Although, the particular role of MSCs in the treatment of diseases is extensively investigated, the MSCs engraftment into diseased organs after blood stream administration and the key mecha­nisms by which MSCs facilitate the repair of organ functions remain undescribed.


Till today, three possible pathways of MSCs implication in tissue regeneration are discussed – a) differentiation of MSCs into organ specific cell type; b) cellular fusion of organ specific cell type with MSCs; c) trophic and/or paracrine effect of MSCs’ secreted molecules. Comprehensive in vitro re­search elucidated that MSCs are able to differentiate into chondrocytes, osteocytes, hepatocytes, cardiomyocytes or even astrocytes and the vast of animal studies revealed the organ function im­provement after MSCs administration indicating rather the trophic and/or paracrine effect of MSCs’ secreted molecules. However, the detailed description of particular ligands, receptors, downstream signaling pathways and functional changes at subcellular and cellular levels is missing.


The aims of the project will be a) to establish appropriate in vitro and in vivo models to examine MSCs regenerative potential; b) to investigate how MSCs are attracted into the site of injury after systemic application; c) to investigate how MSCs react on pathological conditions of diseased organ after in situ application; and d) to investigate which mechanisms are applied by MSCs to restore organ functions.


Additional Information

http://www.biomedic-plzen.cz/en/217-laboratory-of-cellular-regenerative-medicine


Qualifications


  • Ph.D. degree in physiology/biology/life sciences – recently graduated.

  • Practical experience with cell culture, cellular physiology assays (proliferation, adhesion, mig­ration), fluorescent and/or confocal microscopy and live cell imaging, gene and protein expre­ssion analysis (qPCR, microarray technology, ELISA, western blot), immunocytochemistry, flow cytometry, cell sorting.

  • Practical experience with small animal models handling.

  • High motivation, desire to undertake significant/cutting-edge scientific research, team spirit as well as capable of independent work, organization skills (collaborative research, project/grant management), communication skills (in the research team, inter-group, presentation of scientific results).

  • Track record of at least 4 topic related publications in impacted journals (IF > 2), at least 2 of them as the first author.

  • Excellent English communication at both written and oral level.


The applicants should submit


  • Curriculum vitae

  • List of publications

  • Two letters of reference

  • Brief description of prior research, skills and experiences (no more than one page)

  • Copy of university diplom




Faculty of Pharmacy in Hradec Králové


Position of post-doc Researcher at Faculty of Pharmacy in Hradec Králové, Charles University.


Topic: „Development of novel concepts of automation of sample pretreatment procedures and approaches of on-line hyphenation with separative analytical methodologie“


The applicant will become a member of the internationally oriented „Analytical Chemistry Group“ for 2 years, starting on 1.1.2017 (Head of the group: prof. RNDr. Petr Solich, CSc.).


For details about current research of the ACG group please go to: http://portal.faf.cuni.cz/Groups/Analytical-Chemistry-Group/




Faculty of Science


1. Artificial cell – an integrated in vitro model based on specific electrochemical biosensing systems


About ten thousands to millions DNA damage events occur in a human cell per day, causing, among others, the organism aging, and representing a potential risk of the development of serious human diseases including cancer and neurodegeneration. In the last decade, increasing attention has been paid to the binding of small organic molecules to nucleic acids. Such in vitro studies have a key importance for a detailed understanding to these supramolecular interactions, especially in terms of DNA damage. There are four pivotal moments in the fate of a xenobiotic organic compound during its path to induce DNA damage in a human cell: (i) its transport from the living/working environment to the outer cellular environment, (ii) its transport across the cell membrane, (iii) its biotransformation (usually via a cascade of enzymatic reactions), and (iv) its direct interaction with DNA.


Electrochemical techniques represent a set of very useful tools for monitoring the xenobiotics and their redox transformations in various environments. Their advantages have led us to start the development of an artificial cell in which each of the aforementioned stages of the xenobiotics can be investigated in vitro. Having extensive experiences with electrochemical investigation and detection of various genotoxic organic compounds in the living/working environment, we have recently moved our attention to the development of various electrochemical DNA biosensors giving us the chance to investigate the mutual interaction between the xenobiotic and DNA. Very recently, we have also started with electrochemical studies devoted to the transport of low molecular weight organic compounds across the artificial cell membrane (unmodified and protoplast-modified model phospholipid membranes) and their electrochemical or enzymatic transformation.


The concept of the artificial cell, representing an integrated system comprising specific biotransformation and electrochemical biosensing systems, could serve in the near future as an alternative for investigations momentarily performed using living (cultured) human or animal cells, e.g., within biological studies in clinical analysis, drug discovery, and pharmaceutical development processes. Although still an artificial model, it brings new features (arising from employing the electrochemical strategies and not so common in many biochemical and biological studies) such as operational simplicity, detection sensitivity and reliability, high analysis throughput at relatively low cost, and easy automation of individual procedures.


The candidate will be expected to carry out the development and testing of novel DNA biosensors (for investigation of mutual interactions between DNA and the analyte, and for its determination) and enzymatic biosensors (for investigation of enzymatic transformations of the analyte, and for its determination) based on non-traditional electrode materials and nanomaterials. Special emphasis will also be placed on the investigation of the analyte transport across the artificial cell membranes. The investigated analytes will be (but not limited to) anticancer drugs, chemical carcinogens, and reactive radical species. The project involves active collaboration with the groups of Assoc. Prof. Miroslav Fojta (Institute of Biophysics of the AS CR, Brno) and Assoc. Prof. Tomáš Navrátil (J. Heyrovský Institute of Physical Chemistry of the AS CR, Prague).


Contact person and supervisor of the project:

Assoc. Prof. RNDr. Vlastimil Vyskočil, Ph.D.

Head of the Group of Electrochemical Biosensors and Bioelectrochemistry

UNESCO Laboratory of Environmental Electrochemistry

Department of Analytical Chemistry

Faculty of Science

Charles University in Prague

Hlavova 8, 128 43 Prague 2, Czech Republic

tel.: +420-221 951 599, fax: +420-224 913 538, e-mail:

web: https://www.natur.cuni.cz/chemistry/analchem/research-and-science/groups/laboratory-of-environmental-electrochemistry



2. Development of New Pathways for Syntheses of Functional Aromatic Compounds


Research group: Catalysis in Organic Synthesis


Annotation:                  


The main theme of the project is development of new catalytic systems and pathways for synthesis of regioselectively substituted aromatic or heteroaromatic rings based on a transition metal complex [2+2+2]cyclotrimerization of alkynes or alkynes with nitriles. The main objectives of the project is developed new synthetic method suitable for application in syntheses of natural compounds and new materials possessing the fluorene or pyridine scaffold.                                              


As for the former, attention will be focused on synthesis of natural compounds possessing benzene of pyridine rings as an integral of the more complex carbon skeleton such as selaginpulvilin A, granulolactone, pyristriatins, etc.                                           


As for the latter, the effeorts should concentrate on synthesis of fluorene-type compounds as potential precursor for OLEDs. These compounds encompass substances bearing spirobifluorene, spiroindenofluorene, etc. scaffolds. The above mentioned projects are based on results obtained in our laboratory and stem from our long-term interest in aromatic compounds, their synthesis, and their wider application in other fields of chemistry. 


Contact person:         

Prof. Martin Kotora

Department of Organic Chemistry, Faculty of Science

Charles University in Prague

Hlavova 8, 128 43 Praha 2, Czech Republic

Phone:   +420 221 951 334

Fax:         +420 221 951 326

E-mail: 

WEB: http://orgchem.natur.cuni.cz/kotora/



3. Searching for cellular determinants of auxin carrier positioning at the plasma membrane


Plant hormone auxin plays an important morphoregulatory role during the development of sessile plant body (Vanneste and Friml, 2009). The setting of auxin concentration gradients in the plant tissues depends largely on the activity and localization of its influx and efflux plasma membrane transporters from AUX1/LIKE AUX1 (AUX1/LAX), PIN and ABCB protein families(Petrášek and Friml, 2009). To the various, developmentally regulated extents, all of these carriers are recycled between plasma membrane and endomembrane compartments by endosomal recycling pathways (Luschnig and Vert, 2014). Although the molecular machinery that regulate plant vesicle trafficking processes and the role of auxin in this process is intensively studied (Offringa and Huang, 2013), the trafficking of individual auxin carriers and mechanisms of their plasma membrane positioning are described only fragmentary.


In our laboratory, we follow the dynamics of auxin carriers within the plasma membrane and showed that they it dependent on cytoskeletal structures (Laňková et al., 2016). We search for highly motivated postdoc for the identification of new protein determinants of auxin carriers plasma membrane positioning. The project will be focused on the immunoaffinity isolation of candidates isolated from “membrane ghosts” (Krtková et al., 2012), i.e. the fraction of plasma membrane integral and associated proteins isolated from protoplasts. This protocol will be applied to the set of Arabidopsis thaliana lines mutated in genes coding for cytoskeleton and cytoskeleton-associated proteins and enzymes of sterol biosynthesis. Matrix-assisted laser desorption/ionization spectra (MALDI) will be used for the identification of candidate proteins, which will be analysed further by immunofluorescence techniques and electron microscopy techniques.


References:


Krtková, J., Zimmermann, A., Schwarzerová, K., and Nick, P. (2012b). Hsp90 binds microtubules and is involved in the reorganization of the microtubular network in angiosperms. J. Plant Physiol. 169: 1329–39.


Laňková, M., Humpolíčková, J., Vosolsobě, S., Cit, Z., Lacek, J., Čovan, M., Čovanová, M., Hof, M., Petrášek, J.: Determination of dynamics of plant plasma membrane proteins with fluorescence recovery and raster image correlation spectroscopy. Microscopy and Microanalysis 22, 290-299, 2016.


Luschnig, C. and Vert, G. (2014). The dynamics of plant plasma membrane proteins: PINs and beyond. Development 141: 2924–38.


Petrášek, J. and Friml, J. (2009). Auxin transport routes in plant development. Development 136: 2675–88.


Offringa, R. and Huang, F. (2013). Phosphorylation-dependent trafficking of plasma membrane proteins in animal and plant cells. J. Integr. Plant Biol. 55: 789–808.


Vanneste, S. and Friml, J. (2009). Auxin: a trigger for change in plant development. Cell 136: 1005–16.


Contact:


RNDr. Jan Petrášek, Ph.D.

Department of Experimental Plant Biology

Faculty of Science, Charles University in Prague

Viničná 5

128 44 Praha 2

Czech Republic


Researcher ID: C-8240-2009


Tel: 00420 221 951 692



4. Computational modelling of polyelectrolyte gels


The core of the project is the study of behaviour of polyelectrolyte gels under varying conditions using coarse-grained simulations and numerical mean-field models. These gels exhibit stimuli-responsive properties, which vary with external conditions, such as temperature, pH and the presence of salt ions, with promising potential applications, e.g. in controlled release or water desalination. Their behaviour is a result of complex interplay of ionization of the polymer, its conformation and of the external conditions. In the proposed project we use coarse-grained simulations to gain molecular-level understanding of the involved processes, which should enable better exploitation of the application potential. Because such simulations are computationally very demanding, we also employ the numerical mean-field approach as a more approximate and computationally cheaper alternative.


The candidate will be expected to carry out coarse-grained simulations and mean-field calculations of polyelectrolyte gels in various environments (pH, salt, other ions of complex structure). For this purpose we provide a specialized software, or use the open-source package ESPResSo (www.espressomd.org). Optionally, the candidate may also participate in method and software development.


The project involves international collaboration with the groups of prof. F. Leermakers (Wageningen, NL), prof. C. Holm (University of Stuttgart, DE), and Dr. O. Borisov (University of Pau, FR).


Profile of an ideal candidate:


  • Completed PhD at the time of application, but not more than 10 years since its completion, fulfilment of other conditions prescribed by the University (required)

  • Good knowledge of English (FCE equivalent or better)

  • Background in soft matter and statistical mechanics

  • Experience with molecular simulation, programming and Linux OS


Project supervisor: Dr. Peter Košovan


Contact:

+420-221-591-290

Soft Matter research group (http://web.natur.cuni.cz/~kosovan1/softmatter/)

Department of Physical and Macromolecular Chemistry

Faculty of Science, Charles University in Prague

Hlavova 8, 128 43 Prague, Czech Republic



5. Development of synergistic catalysis (DESYNC)


Formation of new C-C and C-heteroatom bonds represents one of the main stream of organic chemistry. Among many synthetic tools and methodologies asymmetric catalysis and attract considerable attention of organic chemists, due to its wide utility. Nevertheless both traditional concepts, transition metal-catalyzed and organocatalyzed transformation have several limitations. Synergistic catalysis, in which two catalytic cycles involving two separate catalysts work in concerted fashion to create a single or more new bonds, has emerged as a powerful approach for the development of new reactions. While synergistic catalysis is more prevalent in nature, the principle has now begun to emerge as a recognized and valued approach to bond-forming processes in organic chemistry. Several examples of synergistic catalysis merging organocatalytic and organometallic approaches were developed, however, the use of a simple metallic Lewis acid and organic Lewis base as a synergistic catalytic system has been less extensively explored. Therefore, the aim of this project is to explore the area of synergistic catalysis using secondary and tertiary aminocatalysis in combination with traditional palladium or other transition-metal chemistry.


The project consists of three parts:


1) Development of cascade reactions based on synergistic catalysis or multicatalysis affording cyclic compounds from commercially available starting materials .


2) Construction of spirocyclic compound based on cascade reactions using heterocyclic compound in combination with alleonates.


3) Application and optimization of developed processes in order to provide direct access towards complex molecules of potential biological activity or synthetic importance.


Supervisor: doc. RNDr. Jan Veselý, Ph.D., Dept. of Organic Chemistry, Faculty of Science, Charles University in Prague


Contact: , tel.: +420 221 951 305



6. A postdoc position at the Department of Botany, Faculty of Science, Charles University


We search one postdoctoral student for the Department of Botany in one of the following fields:


Mechanisms allowing species to adapt to changing climate (responsible person: Zuzana Münzbergová)


The aim of the project is to assess the mechanisms allowing species to adapt to changing climate. It will do so by combining extensive dataset on wide range of species traits related to plant growth and physiology for species originating from different climatic conditions grown in different conditions with data on genetic patterns in the species using both data from neutral markers and data on gene expression of specific genes related to important species traits. In addition, we will aim at understanding the importance of epigenetic variation for species adaptation to the climate. The project will work both at within species level as well as compare wider range of closely related species from different climatic conditions. Importance of plant interactions with other trophic levels will also be considered.


Cryptic speciation in fungi(responsible person: Ondřej Koukol)


Multiphasic approach to resolve cryptic speciation in Pezizales (Ascomycota). Vital taxonomy, axenic cultures and multigene molecular analysis data will be combined to identify and characterise phylogenetic lineages within operculate discomycetes associated with coniferous taxa in Central and South-Eastern Europe. The study of living structures in both teleomorphic and anamorphic states is indispensable at the species level, but ths method provides also valuable markers and reliable recognition at generic level and higher taxa, often demonstrating high overlapping with the phylogenetic trees obtained by multigene molecular analysis. Recent findings indicate that diverse phylogenetic lineages may be identified based on molecular data in members of Pezizales. Multiphasic approach is needed for reliable intepretation of the phylogenetic status of these lineages.


Community ecology of unconventional functional traits (responsible person: Tomáš Herben)


During the past few years, we have been collecting comparative data on novel plant functional traits. They have been collected to provide other dimensions of plant interspecific differentiation, and to complement existing trait data with information more relevant to species dynamics in the field. These involve: plastic response to light and nutrient heterogeneity signals; seed and clonal reproduction in optimum conditions; phenology and growth dynamics; seed nutrient stoichiometry. Further, there is a possibility to collaborate with a group dealing with genome size and other cell-level traits, and with a group possessing data on clonal traits. All these data constitute traits that go far beyond routine traits used in studies of community assembly, and open the possibility to examine role of such novel traits in structuring plant communities and their assembly, taking into account their possible interrelationships and phylogenetic patterns. We are seeking a candidate who will link these data with data on species co-occurrence patterns from regional (e.g. Czech) and European (EVA - European Vegetation Archive) databases and search for nonrandom patterns of trait distribution. At the same time, we expect the candidate to run additional experiments/data collecting to fill gaps in these comparative data.


The applicants should choose one of these subjects. Only one applicant (irrespective of the subject) will be selected, based on his/her past credentials, publication record and good ideas on the subject.  The candidate is expected, apart from work on one of the topics above, to contribute with his/her own ideas to the project: good new ideas from the candidate are most welcome. The successful applicant is also expected to bring new expertise to the department.




Projekt supervisor: prof. RNDr. Tomáš Herben, CSc. 


Contact:

+420 221 95 1653

Department of Botany

Benátská 2, 128 43 Prague, Czech Republic



Faculty of Social Sciences


1. Postdoc in Finance


Contact person: PhDr. Martin Gregor, Ph.D.


We are looking to hire a Postdoc in the field of Finance to carry on her-his research activities in finance and in particular on the following topics: Financial intermediation, Risk management, Financial institutions, Financial regulation, Asset pricing, Macro-finance modeling. We especially welcome applications from the researchers with solid theoretical and quantitative background in finance.


The Postdoc will be part of the Institute of Economic Studies, Faculty of Social Sciences, Charles University in Prague and will become an active member of the Institute, including attending seminars, and all around member of the economics and finance community at Charles University in Prague. In addition, the Postdoc will support teaching and research activities of the department.


Starting date: January 1, 2017


The candidate should hold a PhD in Economics, or at least have a scheduled graduation date. The funding is competitive, and in principle for 2 years. It is expected to lead to a full-time academic placement after the Postdoc period.


The salary is in the range around 1,200 euro/month after-tax, which is rather high relative to the salaries and cost of living in Prague. There are also generous annual research bonuses based on the quality of publications.


Applications include CV, motivation letter, a job market paper and ideally 2 letters of references by August 31, 2016. Candidates should be available for a Skype interview.


You can apply for this job no later than August 31, 2016 via the online application tool at the Faculty of Social Sciences, Charles University in Prague.


Charles University in Prague carries out an equal opportunity policy.


For more information please contact Head of Institute of Economic Studies, Dr. Martin Gregor by mail: .





2. Europeanization of Czech research policy in the Central European context and its limits


Contact person: Mgr. Tomáš Weiss, M.A., Ph.D.


Email:


European Union membership of Central European countries, including the Czech Republic, has impacted (Europeanized) all areas of public policies, be it through the channels of legislative obligation, financial motivation or ideational inspiration. Research policy is no exception in this respect. Czech Republic and other Central European countries participate in the creation of the European Research Area, which aims at higher mobility, exchange of ideas and support of excellence across the European Union. Research policies, research institutions and individual researchers need to reflect the European-wide definition of priorities, objectives and key concepts, such as excellence and interdisciplinarity. At the same time, the Central European countries have, so far, not been able to use the opportunities offered by the ERA to full extent and lag behind in many indicators.


 The project should contribute to better understanding of the mechanisms and results of the Central European (and particularly Czech) participation in the European Research Area. It should identify the root causes of the current situation, the main obstacles and room for possible improvement in Central European context. It may focus on the level of structure or of individual researchers. It should answer specific questions, such as: Who decides about what gets researched? How and by what criteria is that decision made? How does that transform the research environment, economy and society? What are the examples of good practice in individual researchers’ and institutions’ involvement in ERA?




3. Repatriating Native North American Sacred Objects and Remains from European Museums: Recent Cases, Potential Collections, Best Practices.


Contact person: Ing. Mgr. Magdaléna Fiřtová, Ph.D.


Email:


The long-lasting fascination of Europeans with Native Americans resulted in the existence of numerous collections of Native art, daily objects, spiritual objects, clothing, and in some cases human remains, housed in museums throughout Europe. Native American nations have been attempting to repatriate some of these objects, especially those with spiritual value and human remains. Some of these attempts were successful, for example, in 1999 the Kelvingrove Gallery in Glasgow returned a Lakota Ghost Dance Shirt to the Lakota nation. Other such attempts failed, as in the case of French auction houses that have repeatedly ignored pleas from the Hopi and sold their sacred Kachina masks and dolls to the highest bidder. The museum collections, auction sales, and Native American repatriation demands often spark controversies and discussions about collective memory, cultural ownership and identity, sensitivity, and the objects’ value for science and education.


This call proposes to compile a general inventory of Native American collections in European museums, concentrating on the Czech Republic, Slovakia, and Germany (with possible control studies in other countries like the UK etc.), and to study the provenance of selected Native objects in them. Knowledge about these collections and the items they contain will allow for making a prediction about the likelihood of attempts to repatriate them; who may be interested in their repatriation and why, and whether they would have a strong case.


Utilizing scholarly literature on European Museums; The Native American Graves Protection and Repatriation Act (NAGRPA, its processes, effects and challenges; and on Native American memory and American Indian museums, this call would contribute to discussions about cultural appropriation and ownership, but also the representation of Native Americans in the European space, and collective memory and the legacies of colonialism. Formulating best practices for museums with Native collections can offer a practical implementation for institutions with ethnographic collections including Native American objects, such as the Náprstek Museum in Prague and the Chateau Opočno.




4. Democracy, collective action, mobilization, protest and repression


Contact person: doc. PhDr. Michel Perottino, Ph.D.


Email:


Modern democracies have to face from time to time specific collective actions, often somewhere between classical political or social mobilization and various forms of protest more or less violent (strike, demonstration and so on, violent action should appear for instance on margins of officially allowed and eventually supported protests, as we have seen in France for instance during the Spring 2016). How do these phenomena appear and how can democracies cope with them? Where are the limits of legitimate action and when and how can the repression appear? The problem is not new indeed, but are the solution still the same? Can we learn from the past or are the new democratic societies too different face to face with the new possibilities of the social media and so on?




5. Common Security and Defence Policy of the European Union: Technology and Capacity


Contact person: doc. PhDr. Jan Karlas, Ph.D.


Email:


This research theme deals with the Common Security and Defence Policy (CSDP) of the European Union (EU), with the focus on its technological dimension and capacities. The CDSP as such becomes now even more crucial due to two concrete developments: a) the increasing threat of global terrorism and aggressive tendencies of some states, b) the negative result of the British referendum on EU membership, and the related at least potentially diminished prospects of a further European integration. Due to those two reasons, it is of utmost importance to analyse how the EU proceeded and is able to proceed further in the CSDP.


The technological dimension, and the related capacities, constitutes a key area of the CSDP. In this area, the established European institutions have tried to support the needed technological development. In spite of the considerable effort invested by those institutions into the building of common capacities, the results of their work remain modest and controversial. At the same time, the existing research has not devoted an adequate attention to the driving forces behind the CSDP development, as well as its limited effectiveness, in the respective field.


Given this state of affairs, a project carried out within this research theme could address, inter alia, the following research questions:


- What are the preferences of the main actors concerning the development of the technological dimension of the CSDP?


- What explains the particular outcomes that the CSDP reached with regard to technology and capacities?


- What are the key and most promising strategies for strengthening the technological basis of a common European defence?




6. Identities, rules and norms in crisis: contemporary international politics between Russia, the West and Central-Eastern Europe


Contact person: JUDr. PhDr. Tomáš Karásek, Ph.D.


Email:


The research project will explore the dynamics of international politics in Russia, Western and Central-East Europe before and after the Ukraine and the Middle East crises. It will focus on the ongoing change in identities, rules and norms as both an outcome and key factor contributing to the existing ruptures in international order. A key component of the research project is examination of the Russian discourses and practices that construct new identities and regional geopolitical imaginaries in Europe and the so-called post-Soviet ‘near abroad’ and redefine Russia’s relations with Europe as its constitutive Other. The project will also trace the links between Russia’s international promotion of its “conservative Europe” vision with its emphasis on nationalism, sovereignty and “traditional values” and the rise of anti-liberal and anti-European integration forces in the European Union itself. It will look into how existing ruptures in the European project created by the migration crisis and Brexit are being filled in and instrumentalized by outside actors such as the Kremlin, and will try to assess the ramifications of these actions for national and regional identities, norms and understandings of order and security.




7. Dynamics of sports journalism in Central and Eastern Europe


Contact person: PhDr. Alice Němcová Tejkalová, Ph.D.


Email:


Institute of Communication Studies and Journalism invites international post-docs to apply for a vacancy in the field of sports journalism research. The candidate must have PhD. in Media/Communication Studies (or equivalent field); the degree should be obtained in 2016 or earlier.


The successful post-doc candidate will be a part of quite newly formed team interested in sports journalism studies. The project would focus on dynamics of sports journalism within the Central and Eastern Europe (CEE). Sports myths and stereotypes (in relation to nationalism), celebritization and commercialization of sports journalism, especially connections between sports journalism and sports business are going to be analysed. All those topics strongly resonate within sports journalism studies in broader European context, but have not been very much mapped within CEE region.




First Faculty of Medicine


1.

Ústav biochemie a experimentální onkologie 1. LF UK


Glioblastoma microenvironment: role in tumor progression and therapeutic targeting.


MUDr. Petr Bušek, Ph.D.


2.

Ústav patologické fyziologie 1. LF UK


Role of oncogenic extracellular microRNA in tumor biogenesis and dissemination/ Studium úlohy extracelulárních mikroRNA v biogenezi a šíření nádorů.


Mgr. Vít Pospíšil, Ph.D.


3.

IV. interní klinika 1. LF UK a VFN /Ústav lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN


The role of bilirubin and bilirubin metabolites on neural cell differentiation


Prof.  MUDr. Libor Vítek, Ph.D.


4.

Psychiatrická klinika 1. LF UK a VFN


Mitochondrial drug targets in senescence and neurodegenerative disorders/ Mitochondriální cíle léčiv při stárnutí a neurodegenerativních poruchách


Prof. RNDr. Zdeněk Fišar, Ph.D.


5.

Psychiatrická klinika 1. LF UK a VFN


The perception of pain in patients with Anorexia nervosa (AN) without hyperactivity compared with the AN with hyperactivity and comorbidity with ADHD in adults. / Vnímání bolesti u pacientek s AN bez hyperaktivity v porovnání s AN s hyperaktivitou a komorbiditou s ADHD u dospělých.


Prof. MUDr. Hana Papežová, Ph.D.



6.

III. interní klinika 1. LF UK a VFN


Vyhledávání a vyhodnocování nových potenciálních biomarkerů diabetických komplikací se zaměřením na miRNA u pacientů s diabetem 1. a 2. typu/ Scanning and evaluation of new potential biomarkers of diabetic complications, focusing on miRNA in patients with type 1 and type 2 diabetes


doc. MUDr. Martin Prázný, CSc., Ph.D.




Last change: July 25, 2016 15:22 
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